Ambien with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Ambien (Zolpidem). Most antibiotics do not interfere meaningfully with Zolpidem at 5mg, 10mg, 6.25mg CR, 12.5mg CR, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Sleep Aids and Hypnotics agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Zolpidem at 5mg, 10mg, 6.25mg CR, 12.5mg CR.
Practical guidance
According to the prescribing information for Zolpidem, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Ambien is co-administered. Adjusted 5mg, 10mg, 6.25mg CR, 12.5mg CR dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Ambien during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Zolpidem is metabolised and may need a temporary 5mg, 10mg, 6.25mg CR, 12.5mg CR adjustment. The prescribing pharmacist should review any new antibiotic against the existing Ambien regimen.
Will antibiotics make Ambien stop working? ▾
Most antibiotics do not affect Ambien efficacy. Rifampicin and a few others can lower Zolpidem levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Ambien
- With alcoholAmbien and alcohol — is it safe to drink?
- With foodShould Ambien be taken with food?
- Side effectsAmbien side effects: common, rare and warning signs
- Dosage guideAmbien dosage guide: how much to take and when
- OnsetHow fast does Ambien start working?
- DurationHow long does Ambien last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.