Addyi with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Addyi (Flibanserin). Most antibiotics do not interfere meaningfully with Flibanserin at 100mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Women's Sexual Health agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Flibanserin at 100mg.
Practical guidance
According to the prescribing information for Flibanserin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Addyi is co-administered. Adjusted 100mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Addyi during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Flibanserin is metabolised and may need a temporary 100mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Addyi regimen.
Will antibiotics make Addyi stop working? ▾
Most antibiotics do not affect Addyi efficacy. Rifampicin and a few others can lower Flibanserin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
More on Addyi
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