Paxil vs Desyrel: side-by-side comparison
Paxil (Paroxetine) and Desyrel (Trazodone) both belong to the Antidépresseurs class. They share clinical context but use different active ingredients. The choice between them depends on mechanism nuances, side-effect profile and individual response.
| Property | Paxil | Desyrel |
|---|---|---|
| Active ingredient | Paroxetine | Trazodone |
| Manufacturer | GlaxoSmithKline | Various generics |
| Class | Antidépresseurs | Antidépresseurs |
| Strengths | 10mg, 20mg, 30mg, 40mg | 50mg, 100mg, 150mg, 300mg |
| Forms | tablet | tablet |
What's the same
Paxil and Desyrel both belong to the Antidépresseurs class and are used for partially overlapping indications. The active ingredients — Paroxetine vs Trazodone — share the same therapeutic approach, so many safety and management points carry across both.
Key differences
Meaningful differences are in active ingredient (Paroxetine vs Trazodone), strengths (10mg, 20mg, 30mg, 40mg vs 50mg, 100mg, 150mg, 300mg), forms (tablet vs tablet), and the mechanism, half-life and side-effect nuances that distinguish members of the class.
Mechanism and action
Paxil: La paroxétine inhibe sélectivement le transporteur de recapture de la sérotonine (SERT), augmentant sa disponibilité synaptique. Desyrel: La trazodone est classée parmi les antagonistes des récepteurs de la sérotonine et inhibiteurs de sa recapture (SARI).
When Paxil is preferred
Paxil est autorisé dans la dépression caractérisée, le trouble anxieux généralisé, l'anxiété sociale, le trouble panique, le trouble obsessionnel compulsif et l'état de stress post-traumatique, avec des variations selon les pays.
When Desyrel is preferred
Desyrel (trazodone) est autorisé dans la dépression caractérisée.
Questions fréquentes
Is Paxil or Desyrel better? ▾
There is no single answer. Paxil and Desyrel both belong to the Antidépresseurs class but differ in mechanism nuances, half-life and side-effect profile. Preference depends on the patient, the prescriber and prior response to other therapies.
Can I switch from Paxil to Desyrel? ▾
Switching within the Antidépresseurs class is done under supervision, typically using equivalent doses and a follow-up period to confirm response and tolerance. It is not a self-directed decision.
Do Paxil and Desyrel have the same side effects? ▾
They share many of the Antidépresseurs class side effects, with differences from mechanism and dose. Each medication's prescribing information lists specifics.
More Paxil comparisons
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