Trazodone vs Mirtazapine: side-by-side comparison
Trazodone (Atypical antidepressant / serotonin modulator) and Mirtazapine (Atypical antidepressant (NaSSA)) belong to different therapeutic classes and are rarely substitutes for each other. The comparison is useful when a single patient is weighing both options for adjacent or overlapping needs.
| Property | Trazodone | Mirtazapine |
|---|---|---|
| Therapeutic class | Atypical antidepressant / serotonin modulator | Atypical antidepressant (NaSSA) |
| CAS | 19794-93-5 | 85650-52-8 |
| ATC | N06AX05 | N06AX11 |
| Molecular weight | 371.86 g/mol | 265.36 g/mol |
| Brands with this active ingredient | 1 | 1 |
What they share
Trazodone and Mirtazapine share the common regulatory framework for prescription active ingredients, bioequivalence standards for generics, and pharmacist oversight. Beyond that, points in common are limited.
Key differences
Trazodone acts by a different mechanism than Mirtazapine, with indications that barely overlap. Comparing the two is useful when a clinician has mentioned both in the same context or the patient wants to understand why one was prescribed instead of the other.
Mechanisms compared
Trazodone: La trazodone est classée parmi les antagonistes des récepteurs de la sérotonine et inhibiteurs de sa recapture (SARI). Mirtazapine: La mirtazapine antagonise les autorécepteurs et hétérorécepteurs α2-adrénergiques présynaptiques, ce qui augmente la libération de noradrénaline et de sérotonine.
Indications compared
Trazodone: La trazodone est autorisée dans la dépression caractérisée. Mirtazapine: La mirtazapine est autorisée dans la dépression caractérisée.
Safety profile
Trazodone: Les effets indésirables fréquents sont la sédation (effet recherché à faible dose), la sécheresse buccale, les vertiges, l'hypotension orthostatique et les céphalées. Mirtazapine: Les effets indésirables fréquents comprennent la sédation (maximale aux faibles doses de 7,5 à 15 mg, paradoxalement moindre aux doses supérieures), l'augmentation de l'appétit, la prise de poids, la sécheresse buccale e…
Questions fréquentes
Is Trazodone better than Mirtazapine? ▾
Trazodone and Mirtazapine are not "better or worse" — they treat different things. The sensible question is which fits your specific need.
Can Trazodone and Mirtazapine be combined? ▾
Whether they can be combined depends on the indications and the interaction profile of each. If both are in a single prescription, the prescriber has weighed it; in self-medication they should never be combined.
Do they have the same side-effect profile? ▾
No — they belong to different classes and have distinct side-effect profiles. Each has its own prescribing information.
Products with Trazodone
Products with Mirtazapine
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