Serotonin-norepinephrine reuptake inhibitor (SNRI)
Who should not take Venlafaxine
A contraindication is a condition under which Venlafaxine (Venlafaxine) should not be taken because the risk outweighs the benefit. Venlafaxine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 37.5mg, 75mg, 150mg dosing range.
Absolute contraindications
According to the prescribing information for Venlafaxine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Venlafaxine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Venlafaxine inhibits the reuptake of both serotonin and norepinephrine at the synapse, with a dose-dependent profile: at low doses (≤75mg) it acts mainly on serotonin like an SSRI, while at higher dos…
Frequently asked questions
Can someone with heart disease take Venlafaxine? ▾
Some forms of heart disease are absolute contraindications for Venlafaxine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Venlafaxine use under specialist supervision. The prescribing information for Venlafaxine should be reviewed.
Is Venlafaxine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Venlafaxine at adjusted lower 37.5mg, 75mg, 150mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Venlafaxine
More on Venlafaxine
- With alcoholVenlafaxine and alcohol — is it safe to drink?
- With foodShould Venlafaxine be taken with food?
- Side effectsVenlafaxine side effects: common, rare and warning signs
- Dosage guideVenlafaxine dosage guide: how much to take and when
- OnsetHow fast does Venlafaxine start working?
- DurationHow long does Venlafaxine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.