Atypical antidepressant / serotonin modulator
Trazodone with thyroid medication (levothyroxine)
Levothyroxine is one of the most prescribed medications worldwide, and many adults on it also use chronic medications such as Trazodone (Trazodone). The combination is generally safe, but levothyroxine's narrow therapeutic index and finicky absorption mean a few practical points matter more than for most other co-administered drugs at 50mg, 100mg, 150mg, 300mg.
How Trazodone affects thyroid medication
Levothyroxine absorption is sensitive to timing relative to food, calcium, iron and several medications. Whether Trazodone interferes depends on Trazodone — most agents in Atypical antidepressant / serotonin modulator have no clinically meaningful effect on thyroid hormone levels, but a small number affect TSH or T4 free fraction. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Practical timing
According to standard endocrine practice, levothyroxine is taken on an empty stomach at least 30 minutes before food and 4 hours from interacting medications. Trazodone at 50mg, 100mg, 150mg, 300mg can usually be taken at any time relative to the levothyroxine dose, but the prescribing information for Trazodone should be checked for specific timing instructions.
Frequently asked questions
Will Trazodone affect my thyroid levels? ▾
Most Atypical antidepressant / serotonin modulator medications do not directly affect thyroid hormone levels at 50mg, 100mg, 150mg, 300mg. Some affect TSH testing, hormone-binding proteins or T4 free fraction in subtle ways. Routine thyroid function tests every few months catch any meaningful drift.
When should I take Trazodone relative to levothyroxine? ▾
Levothyroxine is taken on an empty stomach with at least a 30-minute fast and 4-hour separation from interacting medications. Trazodone at 50mg, 100mg, 150mg, 300mg usually has no specific timing constraint relative to levothyroxine; the pharmacist confirms based on the prescribing information for Trazodone.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.