Atypical antidepressant / serotonin modulator
Trazodone with statins (atorvastatin, rosuvastatin, simvastatin)
Statins are among the most widely prescribed chronic medications, often used alongside many other agents including Trazodone (Trazodone). The combination at 50mg, 100mg, 150mg, 300mg is generally safe, but a small number of statin-specific interactions matter — particularly for simvastatin, which shares CYP3A4 metabolism with several common medications.
How Trazodone interacts with statins
Statins differ in their metabolic pathways: simvastatin and atorvastatin go through CYP3A4 most heavily; rosuvastatin and pravastatin take other routes and have fewer drug interactions. If Trazodone acts on CYP3A4, the combination with simvastatin or atorvastatin can raise statin levels and increase muscle-related side effects. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Practical guidance
According to the prescribing information for Trazodone, anyone on a statin should mention it before starting Trazodone at 50mg, 100mg, 150mg, 300mg. The prescriber may switch the statin (e.g. from simvastatin to rosuvastatin) or adjust the statin dose during Trazodone use. Persistent muscle pain, weakness or dark urine on the combination warrants prompt evaluation.
Frequently asked questions
Can I take Trazodone with my statin? ▾
For most users at 50mg, 100mg, 150mg, 300mg, yes — particularly with rosuvastatin or pravastatin which have minimal interactions with Trazodone. Simvastatin and atorvastatin combinations may need a dose review by the prescriber to avoid amplified statin effects.
Will Trazodone cause muscle pain with my statin? ▾
Muscle pain is the most common statin side effect and can be amplified when combined with medications that raise statin plasma levels. Persistent or new muscle pain on Trazodone at 50mg, 100mg, 150mg, 300mg should be reported promptly so the prescriber can review the combination.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.