Atypical antidepressant / serotonin modulator
Trazodone with painkillers (paracetamol, NSAIDs, aspirin)
Painkillers are among the most commonly co-administered medications with Trazodone (Trazodone), often started without telling the prescriber. Most short-term combinations are safe at the standard 50mg, 100mg, 150mg, 300mg dose, but a few specific painkiller-Trazodone interactions matter and should not be assumed away.
Common painkillers and Trazodone
Paracetamol (acetaminophen) is generally the safest painkiller to combine with Trazodone, with very few documented interactions. NSAIDs (ibuprofen, naproxen, diclofenac) can interact with cardiovascular medications and amplify renal or gastrointestinal risks of Trazodone. Aspirin shares the NSAID profile plus its own bleeding risk. Opioid painkillers add sedative load to many Atypical antidepressant / serotonin modulator agents.
Practical guidance
According to the prescribing information for Trazodone, occasional standard-dose painkiller use is rarely a problem with Trazodone at 50mg, 100mg, 150mg, 300mg. Regular daily NSAID use, high-dose aspirin therapy, or any opioid combination should be reviewed with the prescriber or pharmacist before being added to a routine that already includes Trazodone.
Frequently asked questions
Is paracetamol safe with Trazodone? ▾
Paracetamol at standard adult doses (≤3g/day for short courses) is generally safe to take with Trazodone at 50mg, 100mg, 150mg, 300mg. It is usually the first-line painkiller to combine with chronic medication because of its low interaction profile.
Can I take ibuprofen on Trazodone? ▾
Occasional ibuprofen for short-term pain is usually fine with Trazodone. Daily ibuprofen, NSAIDs in elderly users, or NSAIDs combined with cardiovascular or renal disease deserve a pharmacist review before being routinely added to Trazodone.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.