Atypical antidepressant / serotonin modulator
Trazodone with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Trazodone (Trazodone) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Trazodone at 50mg, 100mg, 150mg, 300mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Atypical antidepressant / serotonin modulator agents.
Practical guidance
According to the prescribing information for Trazodone, any change in antidepressant therapy should be reviewed alongside Trazodone dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Trazodone at the standard 50mg, 100mg, 150mg, 300mg schedule.
Frequently asked questions
Can I take Trazodone on an SSRI? ▾
For most SSRIs and most Atypical antidepressant / serotonin modulator agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Trazodone.
Are there antidepressants to avoid with Trazodone? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Trazodone and the specific antidepressant; a pharmacist review is the practical safeguard at 50mg, 100mg, 150mg, 300mg.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.