Atypical antidepressant / serotonin modulator
Trazodone drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Trazodone (Trazodone) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 50mg, 100mg, 150mg, 300mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Trazodone
For Trazodone, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several Atypical antidepressant / serotonin modulator agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Trazodone. According to the prescribing information for Trazodone, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 50mg, 100mg, 150mg, 300mg.
Frequently asked questions
What's the most important Trazodone interaction to know? ▾
For most Atypical antidepressant / serotonin modulator medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 50mg, 100mg, 150mg, 300mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Trazodone in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 50mg, 100mg, 150mg, 300mg.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.