Atypical antidepressant / serotonin modulator
Who should not take Trazodone
A contraindication is a condition under which Trazodone (Trazodone) should not be taken because the risk outweighs the benefit. Trazodone has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 50mg, 100mg, 150mg, 300mg dosing range.
Absolute contraindications
According to the prescribing information for Trazodone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Trazodone can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Trazodone is classified as a serotonin antagonist and reuptake inhibitor (SARI).
Frequently asked questions
Can someone with heart disease take Trazodone? ▾
Some forms of heart disease are absolute contraindications for Trazodone, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Trazodone use under specialist supervision. The prescribing information for Trazodone should be reviewed.
Is Trazodone safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Trazodone at adjusted lower 50mg, 100mg, 150mg, 300mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Trazodone
More on Trazodone
- With alcoholTrazodone and alcohol — is it safe to drink?
- With foodShould Trazodone be taken with food?
- Side effectsTrazodone side effects: common, rare and warning signs
- Dosage guideTrazodone dosage guide: how much to take and when
- OnsetHow fast does Trazodone start working?
- DurationHow long does Trazodone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.