Synthetic steroid (STEAR)
Who should not take Tibolone
A contraindication is a condition under which Tibolone (Tibolone) should not be taken because the risk outweighs the benefit. Tibolone has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 2.5mg dosing range.
Absolute contraindications
According to the prescribing information for Tibolone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Tibolone can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Tibolone is a prodrug; on absorption it is rapidly converted to three active metabolites (3α-OH-tibolone, 3β-OH-tibolone and Δ4-tibolone) with different tissue-selective activity.
Frequently asked questions
Can someone with heart disease take Tibolone? ▾
Some forms of heart disease are absolute contraindications for Tibolone, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Tibolone use under specialist supervision. The prescribing information for Tibolone should be reviewed.
Is Tibolone safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Tibolone at adjusted lower 2.5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Tibolone
More on Tibolone
- With alcoholTibolone and alcohol — is it safe to drink?
- With foodShould Tibolone be taken with food?
- Side effectsTibolone side effects: common, rare and warning signs
- Dosage guideTibolone dosage guide: how much to take and when
- OnsetHow fast does Tibolone start working?
- DurationHow long does Tibolone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.