PDE5 inhibitor
Who should not take Sildenafil Citrate
A contraindication is a condition under which Sildenafil Citrate (Sildenafil Citrate) should not be taken because the risk outweighs the benefit. Sildenafil Citrate has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 100mg, 50mg, 25mg dosing range.
Absolute contraindications
According to the prescribing information for Sildenafil Citrate, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Sildenafil Citrate can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Sildenafil citrate selectively inhibits phosphodiesterase type 5 (PDE5), an enzyme that breaks down cyclic guanosine monophosphate in the corpus cavernosum.
Frequently asked questions
Can someone with heart disease take Sildenafil Citrate? ▾
Some forms of heart disease are absolute contraindications for Sildenafil Citrate, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Sildenafil Citrate use under specialist supervision. The prescribing information for Sildenafil Citrate should be reviewed.
Is Sildenafil Citrate safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Sildenafil Citrate at adjusted lower 100mg, 50mg, 25mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Sildenafil Citrate
More on Sildenafil Citrate
- With alcoholSildenafil Citrate and alcohol — is it safe to drink?
- With foodShould Sildenafil Citrate be taken with food?
- Side effectsSildenafil Citrate side effects: common, rare and warning signs
- Dosage guideSildenafil Citrate dosage guide: how much to take and when
- OnsetHow fast does Sildenafil Citrate start working?
- DurationHow long does Sildenafil Citrate last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.