Selective serotonin reuptake inhibitor (SSRI)
Who should not take Sertraline
A contraindication is a condition under which Sertraline (Sertraline) should not be taken because the risk outweighs the benefit. Sertraline has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mg, 50mg, 100mg dosing range.
Absolute contraindications
According to the prescribing information for Sertraline, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Sertraline can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Sertraline selectively blocks the reuptake of serotonin (5-HT) by the presynaptic neuron, increasing the concentration of serotonin in the synaptic cleft.
Frequently asked questions
Can someone with heart disease take Sertraline? ▾
Some forms of heart disease are absolute contraindications for Sertraline, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Sertraline use under specialist supervision. The prescribing information for Sertraline should be reviewed.
Is Sertraline safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Sertraline at adjusted lower 25mg, 50mg, 100mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Sertraline
More on Sertraline
- With alcoholSertraline and alcohol — is it safe to drink?
- With foodShould Sertraline be taken with food?
- Side effectsSertraline side effects: common, rare and warning signs
- Dosage guideSertraline dosage guide: how much to take and when
- OnsetHow fast does Sertraline start working?
- DurationHow long does Sertraline last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.