Gabapentinoid (alpha-2-delta ligand)
Pregabalin with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Pregabalin (Pregabalin). Most antibiotics do not interfere meaningfully with Pregabalin at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Gabapentinoid (alpha-2-delta ligand) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Pregabalin at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg.
Practical guidance
According to the prescribing information for Pregabalin, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Pregabalin is co-administered. Adjusted 25mg, 50mg, 75mg, 100mg, 150mg, 200mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Pregabalin during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Pregabalin is metabolised and may need a temporary 25mg, 50mg, 75mg, 100mg, 150mg, 200mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Pregabalin regimen.
Will antibiotics make Pregabalin stop working? ▾
Most antibiotics do not affect Pregabalin efficacy. Rifampicin and a few others can lower Pregabalin levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Pregabalin
More on Pregabalin
- With alcoholPregabalin and alcohol — is it safe to drink?
- With foodShould Pregabalin be taken with food?
- Side effectsPregabalin side effects: common, rare and warning signs
- Dosage guidePregabalin dosage guide: how much to take and when
- OnsetHow fast does Pregabalin start working?
- DurationHow long does Pregabalin last?
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