Leukotriene receptor antagonist
Who should not take Montelukast
A contraindication is a condition under which Montelukast (Montelukast) should not be taken because the risk outweighs the benefit. Montelukast has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 4mg, 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Montelukast, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Montelukast can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Montelukast selectively blocks the CysLT1 receptor, which mediates the action of leukotrienes C4, D4 and E4 — proinflammatory mediators released by mast cells and eosinophils in the airway.
Frequently asked questions
Can someone with heart disease take Montelukast? ▾
Some forms of heart disease are absolute contraindications for Montelukast, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Montelukast use under specialist supervision. The prescribing information for Montelukast should be reviewed.
Is Montelukast safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Montelukast at adjusted lower 4mg, 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Montelukast
More on Montelukast
- With alcoholMontelukast and alcohol — is it safe to drink?
- With foodShould Montelukast be taken with food?
- Side effectsMontelukast side effects: common, rare and warning signs
- Dosage guideMontelukast dosage guide: how much to take and when
- OnsetHow fast does Montelukast start working?
- DurationHow long does Montelukast last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.