Progestin
Medroxyprogesterone with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Medroxyprogesterone (Medroxyprogesterone). Most antibiotics do not interfere meaningfully with Medroxyprogesterone at 2.5mg, 5mg, 10mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Progestin agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Medroxyprogesterone at 2.5mg, 5mg, 10mg.
Practical guidance
According to the prescribing information for Medroxyprogesterone, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Medroxyprogesterone is co-administered. Adjusted 2.5mg, 5mg, 10mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Medroxyprogesterone during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Medroxyprogesterone is metabolised and may need a temporary 2.5mg, 5mg, 10mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Medroxyprogesterone regimen.
Will antibiotics make Medroxyprogesterone stop working? ▾
Most antibiotics do not affect Medroxyprogesterone efficacy. Rifampicin and a few others can lower Medroxyprogesterone levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Medroxyprogesterone
More on Medroxyprogesterone
- With alcoholMedroxyprogesterone and alcohol — is it safe to drink?
- With foodShould Medroxyprogesterone be taken with food?
- Side effectsMedroxyprogesterone side effects: common, rare and warning signs
- Dosage guideMedroxyprogesterone dosage guide: how much to take and when
- OnsetHow fast does Medroxyprogesterone start working?
- DurationHow long does Medroxyprogesterone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.