Benzodiazepine
Lorazepam with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Lorazepam (Lorazepam) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Lorazepam at 0.5mg, 1mg, 2mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Benzodiazepine agents.
Practical guidance
According to the prescribing information for Lorazepam, any change in antidepressant therapy should be reviewed alongside Lorazepam dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Lorazepam at the standard 0.5mg, 1mg, 2mg schedule.
Frequently asked questions
Can I take Lorazepam on an SSRI? ▾
For most SSRIs and most Benzodiazepine agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Lorazepam.
Are there antidepressants to avoid with Lorazepam? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Lorazepam and the specific antidepressant; a pharmacist review is the practical safeguard at 0.5mg, 1mg, 2mg.
Products containing Lorazepam
More on Lorazepam
- With alcoholLorazepam and alcohol — is it safe to drink?
- With foodShould Lorazepam be taken with food?
- Side effectsLorazepam side effects: common, rare and warning signs
- Dosage guideLorazepam dosage guide: how much to take and when
- OnsetHow fast does Lorazepam start working?
- DurationHow long does Lorazepam last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.