Second-generation H1 antihistamine
Who should not take Loratadine
A contraindication is a condition under which Loratadine (Loratadine) should not be taken because the risk outweighs the benefit. Loratadine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 5mg, 10mg dosing range.
Absolute contraindications
According to the prescribing information for Loratadine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Loratadine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Loratadine selectively blocks peripheral H1 histamine receptors, antagonising the effects of histamine released during allergic reactions.
Frequently asked questions
Can someone with heart disease take Loratadine? ▾
Some forms of heart disease are absolute contraindications for Loratadine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Loratadine use under specialist supervision. The prescribing information for Loratadine should be reviewed.
Is Loratadine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Loratadine at adjusted lower 5mg, 10mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Loratadine
More on Loratadine
- With alcoholLoratadine and alcohol — is it safe to drink?
- With foodShould Loratadine be taken with food?
- Side effectsLoratadine side effects: common, rare and warning signs
- Dosage guideLoratadine dosage guide: how much to take and when
- OnsetHow fast does Loratadine start working?
- DurationHow long does Loratadine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.