Thyroid hormone replacement
Skin side effects of Levothyroxine: rash, dryness, photosensitivity
Skin reactions are among the most visible side effects of medication and range from minor cosmetic concerns to medical emergencies. Levothyroxine (Levothyroxine) at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg may produce a range of skin effects depending on Levothyroxine; this page covers what is typical, what is rare, and what calls for stopping the medication.
Common skin effects of Levothyroxine
According to the prescribing information for Levothyroxine, common skin reactions include mild rash, dryness, mild itching, transient flushing and (for some agents) photosensitivity that makes the skin more sensitive to UV. Levothyroxine replaces deficient endogenous thyroxine, which is converted in tissues to the active hormone triiodothyronine (T3) by deiodinase enzymes. Most are mild, appear in the first weeks and resolve without intervention or with simple measures (moisturiser, sunscreen).
Serious skin reactions
Severe skin reactions — Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome — are rare but life-threatening. Warning signs are a rash with fever, mucosal involvement (mouth, eyes), skin peeling, or rapidly spreading rash. Any of these on Levothyroxine at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg is a medical emergency and reason to stop the medication and seek immediate care.
Frequently asked questions
Is a rash on Levothyroxine dangerous? ▾
Most rashes on Levothyroxine at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg are mild and resolve. A rash with fever, mucosal involvement, blistering or rapid spread is not — it requires emergency evaluation and stopping the medication.
Can Levothyroxine cause sunburn or photosensitivity? ▾
Some medications including a subset of Thyroid hormone replacement agents increase UV sensitivity, making sunburn occur faster. The prescribing information for Levothyroxine lists this when documented. Sunscreen and avoiding peak sun exposure manage the risk.
Products containing Levothyroxine
More on Levothyroxine
- With alcoholLevothyroxine and alcohol — is it safe to drink?
- With foodShould Levothyroxine be taken with food?
- Side effectsLevothyroxine side effects: common, rare and warning signs
- Dosage guideLevothyroxine dosage guide: how much to take and when
- OnsetHow fast does Levothyroxine start working?
- DurationHow long does Levothyroxine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.