Antiepileptic (sodium channel blocker)
Who should not take Lamotrigine
A contraindication is a condition under which Lamotrigine (Lamotrigine) should not be taken because the risk outweighs the benefit. Lamotrigine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mg, 50mg, 100mg, 200mg dosing range.
Absolute contraindications
According to the prescribing information for Lamotrigine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Lamotrigine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Lamotrigine is a phenyltriazine that selectively blocks voltage-gated sodium channels, stabilising neuronal membranes and reducing the release of excitatory neurotransmitters, particularly glutamate.
Frequently asked questions
Can someone with heart disease take Lamotrigine? ▾
Some forms of heart disease are absolute contraindications for Lamotrigine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Lamotrigine use under specialist supervision. The prescribing information for Lamotrigine should be reviewed.
Is Lamotrigine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Lamotrigine at adjusted lower 25mg, 50mg, 100mg, 200mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Lamotrigine
More on Lamotrigine
- With alcoholLamotrigine and alcohol — is it safe to drink?
- With foodShould Lamotrigine be taken with food?
- Side effectsLamotrigine side effects: common, rare and warning signs
- Dosage guideLamotrigine dosage guide: how much to take and when
- OnsetHow fast does Lamotrigine start working?
- DurationHow long does Lamotrigine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.