Long-acting insulin analogue
Who should not take Insulin Glargine
A contraindication is a condition under which Insulin Glargine (Insulin Glargine) should not be taken because the risk outweighs the benefit. Insulin Glargine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 100 IU/mL dosing range.
Absolute contraindications
According to the prescribing information for Insulin Glargine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Insulin Glargine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Insulin glargine binds the insulin receptor with similar affinity to human insulin, activating intracellular signalling that increases glucose uptake in muscle and adipose tissue, suppresses hepatic g…
Frequently asked questions
Can someone with heart disease take Insulin Glargine? ▾
Some forms of heart disease are absolute contraindications for Insulin Glargine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Insulin Glargine use under specialist supervision. The prescribing information for Insulin Glargine should be reviewed.
Is Insulin Glargine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Insulin Glargine at adjusted lower 100 IU/mL doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Insulin Glargine
More on Insulin Glargine
- With alcoholInsulin Glargine and alcohol — is it safe to drink?
- With foodShould Insulin Glargine be taken with food?
- Side effectsInsulin Glargine side effects: common, rare and warning signs
- Dosage guideInsulin Glargine dosage guide: how much to take and when
- OnsetHow fast does Insulin Glargine start working?
- DurationHow long does Insulin Glargine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.