Thiazide diuretic
Who should not take Hydrochlorothiazide
A contraindication is a condition under which Hydrochlorothiazide (Hydrochlorothiazide) should not be taken because the risk outweighs the benefit. Hydrochlorothiazide has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 12.5mg, 25mg, 50mg dosing range.
Absolute contraindications
According to the prescribing information for Hydrochlorothiazide, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Hydrochlorothiazide can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Hydrochlorothiazide blocks the sodium-chloride symporter in the distal convoluted tubule of the kidney, reducing sodium reabsorption and producing modest diuresis.
Frequently asked questions
Can someone with heart disease take Hydrochlorothiazide? ▾
Some forms of heart disease are absolute contraindications for Hydrochlorothiazide, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Hydrochlorothiazide use under specialist supervision. The prescribing information for Hydrochlorothiazide should be reviewed.
Is Hydrochlorothiazide safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Hydrochlorothiazide at adjusted lower 12.5mg, 25mg, 50mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Hydrochlorothiazide
More on Hydrochlorothiazide
- With alcoholHydrochlorothiazide and alcohol — is it safe to drink?
- With foodShould Hydrochlorothiazide be taken with food?
- Side effectsHydrochlorothiazide side effects: common, rare and warning signs
- Dosage guideHydrochlorothiazide dosage guide: how much to take and when
- OnsetHow fast does Hydrochlorothiazide start working?
- DurationHow long does Hydrochlorothiazide last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.