Selective serotonin reuptake inhibitor (SSRI)
Who should not take Fluoxetine
A contraindication is a condition under which Fluoxetine (Fluoxetine) should not be taken because the risk outweighs the benefit. Fluoxetine has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 10mg, 20mg, 40mg dosing range.
Absolute contraindications
According to the prescribing information for Fluoxetine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Fluoxetine can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Fluoxetine selectively inhibits the serotonin reuptake transporter, increasing synaptic serotonin availability.
Frequently asked questions
Can someone with heart disease take Fluoxetine? ▾
Some forms of heart disease are absolute contraindications for Fluoxetine, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Fluoxetine use under specialist supervision. The prescribing information for Fluoxetine should be reviewed.
Is Fluoxetine safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Fluoxetine at adjusted lower 10mg, 20mg, 40mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Fluoxetine
More on Fluoxetine
- With alcoholFluoxetine and alcohol — is it safe to drink?
- With foodShould Fluoxetine be taken with food?
- Side effectsFluoxetine side effects: common, rare and warning signs
- Dosage guideFluoxetine dosage guide: how much to take and when
- OnsetHow fast does Fluoxetine start working?
- DurationHow long does Fluoxetine last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.