Triazole antifungal
Fluconazole with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Fluconazole (Fluconazole). Most antibiotics do not interfere meaningfully with Fluconazole at 50mg, 100mg, 150mg, 200mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Triazole antifungal agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Fluconazole at 50mg, 100mg, 150mg, 200mg.
Practical guidance
According to the prescribing information for Fluconazole, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Fluconazole is co-administered. Adjusted 50mg, 100mg, 150mg, 200mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Fluconazole during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Fluconazole is metabolised and may need a temporary 50mg, 100mg, 150mg, 200mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Fluconazole regimen.
Will antibiotics make Fluconazole stop working? ▾
Most antibiotics do not affect Fluconazole efficacy. Rifampicin and a few others can lower Fluconazole levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Fluconazole
More on Fluconazole
- With alcoholFluconazole and alcohol — is it safe to drink?
- With foodShould Fluconazole be taken with food?
- Side effectsFluconazole side effects: common, rare and warning signs
- Dosage guideFluconazole dosage guide: how much to take and when
- OnsetHow fast does Fluconazole start working?
- DurationHow long does Fluconazole last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.