Synthetic estrogen / contraceptive
Ethinyl Estradiol with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Ethinyl Estradiol (Ethinyl Estradiol). Most antibiotics do not interfere meaningfully with Ethinyl Estradiol at 3mg / 0.03mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Synthetic estrogen / contraceptive agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Ethinyl Estradiol at 3mg / 0.03mg.
Practical guidance
According to the prescribing information for Ethinyl Estradiol, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Ethinyl Estradiol is co-administered. Adjusted 3mg / 0.03mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Ethinyl Estradiol during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Ethinyl Estradiol is metabolised and may need a temporary 3mg / 0.03mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Ethinyl Estradiol regimen.
Will antibiotics make Ethinyl Estradiol stop working? ▾
Most antibiotics do not affect Ethinyl Estradiol efficacy. Rifampicin and a few others can lower Ethinyl Estradiol levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Ethinyl Estradiol
More on Ethinyl Estradiol
- With alcoholEthinyl Estradiol and alcohol — is it safe to drink?
- With foodShould Ethinyl Estradiol be taken with food?
- Side effectsEthinyl Estradiol side effects: common, rare and warning signs
- Dosage guideEthinyl Estradiol dosage guide: how much to take and when
- OnsetHow fast does Ethinyl Estradiol start working?
- DurationHow long does Ethinyl Estradiol last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.