Proton pump inhibitor
Who should not take Esomeprazole
A contraindication is a condition under which Esomeprazole (Esomeprazole) should not be taken because the risk outweighs the benefit. Esomeprazole has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 20mg, 40mg dosing range.
Absolute contraindications
According to the prescribing information for Esomeprazole, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Esomeprazole can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Esomeprazole is a substituted benzimidazole prodrug that is activated in the acidic environment of the gastric parietal cell, where it irreversibly inhibits the H+/K+-ATPase enzyme — the proton pump r…
Frequently asked questions
Can someone with heart disease take Esomeprazole? ▾
Some forms of heart disease are absolute contraindications for Esomeprazole, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Esomeprazole use under specialist supervision. The prescribing information for Esomeprazole should be reviewed.
Is Esomeprazole safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Esomeprazole at adjusted lower 20mg, 40mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Esomeprazole
More on Esomeprazole
- With alcoholEsomeprazole and alcohol — is it safe to drink?
- With foodShould Esomeprazole be taken with food?
- Side effectsEsomeprazole side effects: common, rare and warning signs
- Dosage guideEsomeprazole dosage guide: how much to take and when
- OnsetHow fast does Esomeprazole start working?
- DurationHow long does Esomeprazole last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.