Selective serotonin reuptake inhibitor (SSRI)
Escitalopram with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Escitalopram (Escitalopram). Most antibiotics do not interfere meaningfully with Escitalopram at 5mg, 10mg, 20mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Selective serotonin reuptake inhibitor (SSRI) agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Escitalopram at 5mg, 10mg, 20mg.
Practical guidance
According to the prescribing information for Escitalopram, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Escitalopram is co-administered. Adjusted 5mg, 10mg, 20mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Escitalopram during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Escitalopram is metabolised and may need a temporary 5mg, 10mg, 20mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Escitalopram regimen.
Will antibiotics make Escitalopram stop working? ▾
Most antibiotics do not affect Escitalopram efficacy. Rifampicin and a few others can lower Escitalopram levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Escitalopram
More on Escitalopram
- With alcoholEscitalopram and alcohol — is it safe to drink?
- With foodShould Escitalopram be taken with food?
- Side effectsEscitalopram side effects: common, rare and warning signs
- Dosage guideEscitalopram dosage guide: how much to take and when
- OnsetHow fast does Escitalopram start working?
- DurationHow long does Escitalopram last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.