GLP-1 receptor agonist
Dulaglutide with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Dulaglutide (Dulaglutide). Most antibiotics do not interfere meaningfully with Dulaglutide at 0.75mg, 1.5mg, 3mg, 4.5mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some GLP-1 receptor agonist agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Dulaglutide at 0.75mg, 1.5mg, 3mg, 4.5mg.
Practical guidance
According to the prescribing information for Dulaglutide, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Dulaglutide is co-administered. Adjusted 0.75mg, 1.5mg, 3mg, 4.5mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Dulaglutide during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Dulaglutide is metabolised and may need a temporary 0.75mg, 1.5mg, 3mg, 4.5mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Dulaglutide regimen.
Will antibiotics make Dulaglutide stop working? ▾
Most antibiotics do not affect Dulaglutide efficacy. Rifampicin and a few others can lower Dulaglutide levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Dulaglutide
More on Dulaglutide
- With alcoholDulaglutide and alcohol — is it safe to drink?
- With foodShould Dulaglutide be taken with food?
- Side effectsDulaglutide side effects: common, rare and warning signs
- Dosage guideDulaglutide dosage guide: how much to take and when
- OnsetHow fast does Dulaglutide start working?
- DurationHow long does Dulaglutide last?
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