Progestogen with anti-mineralocorticoid and anti-androgen activity
Drospirenone drug interactions: a practical overview
Drug interactions are the single biggest cause of preventable medication problems. Drospirenone (Drospirenone) interacts to varying degrees with several classes of medication and with a smaller list of foods. This page summarises the practically important ones at 3mg / 0.03mg, 3mg/0.02mg, framed for a real-world prescription review rather than an exhaustive PDF list.
High-priority interactions for Drospirenone
For Drospirenone, the most clinically relevant interactions are typically with strong CYP3A4 inhibitors and inducers, with cardiovascular medications (notably nitrates for several Progestogen with anti-mineralocorticoid and anti-androgen activity agents), with central nervous system depressants, and with medications affecting blood pressure or heart rate. Drospirenone activates progesterone receptors to suppress ovulation and produce the contraceptive effect when combined with an estrogen.
Working with the pharmacist
A pharmacist review of all current medications is the practical safeguard against unintended interactions with Drospirenone. According to the prescribing information for Drospirenone, the full medication list — prescription, OTC, supplements and recreational substances — should be reviewed before starting and at every dose change at 3mg / 0.03mg, 3mg/0.02mg.
Frequently asked questions
What's the most important Drospirenone interaction to know? ▾
For most Progestogen with anti-mineralocorticoid and anti-androgen activity medications, the highest-priority interaction is with nitrate medications used for chest pain — this combination is often a hard contraindication. After that, strong CYP3A4 inhibitors (some antifungals, macrolides) are the next concern at routine 3mg / 0.03mg, 3mg/0.02mg doses.
Do I need to tell the pharmacist about supplements? ▾
Yes. Supplements and herbal products can interact with Drospirenone in ways that prescription drug-drug interaction databases miss. The pharmacist needs the complete picture — including supplements like St John's Wort, grapefruit-containing products and high-dose vitamins — to flag risks at 3mg / 0.03mg, 3mg/0.02mg.
Products containing Drospirenone
More on Drospirenone
- With alcoholDrospirenone and alcohol — is it safe to drink?
- With foodShould Drospirenone be taken with food?
- Side effectsDrospirenone side effects: common, rare and warning signs
- Dosage guideDrospirenone dosage guide: how much to take and when
- OnsetHow fast does Drospirenone start working?
- DurationHow long does Drospirenone last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.