NSAID (phenylacetic acid)
Skin side effects of Diclofenac: rash, dryness, photosensitivity
Skin reactions are among the most visible side effects of medication and range from minor cosmetic concerns to medical emergencies. Diclofenac (Diclofenac) at 25mg, 50mg, 75mg, 100mg may produce a range of skin effects depending on Diclofenac; this page covers what is typical, what is rare, and what calls for stopping the medication.
Common skin effects of Diclofenac
According to the prescribing information for Diclofenac, common skin reactions include mild rash, dryness, mild itching, transient flushing and (for some agents) photosensitivity that makes the skin more sensitive to UV. Diclofenac reversibly inhibits cyclooxygenase enzymes COX-1 and COX-2, with somewhat greater selectivity for COX-2 than ibuprofen and naproxen. Most are mild, appear in the first weeks and resolve without intervention or with simple measures (moisturiser, sunscreen).
Serious skin reactions
Severe skin reactions — Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome — are rare but life-threatening. Warning signs are a rash with fever, mucosal involvement (mouth, eyes), skin peeling, or rapidly spreading rash. Any of these on Diclofenac at 25mg, 50mg, 75mg, 100mg is a medical emergency and reason to stop the medication and seek immediate care.
Frequently asked questions
Is a rash on Diclofenac dangerous? ▾
Most rashes on Diclofenac at 25mg, 50mg, 75mg, 100mg are mild and resolve. A rash with fever, mucosal involvement, blistering or rapid spread is not — it requires emergency evaluation and stopping the medication.
Can Diclofenac cause sunburn or photosensitivity? ▾
Some medications including a subset of NSAID (phenylacetic acid) agents increase UV sensitivity, making sunburn occur faster. The prescribing information for Diclofenac lists this when documented. Sunscreen and avoiding peak sun exposure manage the risk.
Products containing Diclofenac
More on Diclofenac
- With alcoholDiclofenac and alcohol — is it safe to drink?
- With foodShould Diclofenac be taken with food?
- Side effectsDiclofenac side effects: common, rare and warning signs
- Dosage guideDiclofenac dosage guide: how much to take and when
- OnsetHow fast does Diclofenac start working?
- DurationHow long does Diclofenac last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.