Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant
Skin side effects of Bupropion: rash, dryness, photosensitivity
Skin reactions are among the most visible side effects of medication and range from minor cosmetic concerns to medical emergencies. Bupropion (Bupropion) at 75mg, 100mg, 150mg, 300mg may produce a range of skin effects depending on Bupropion; this page covers what is typical, what is rare, and what calls for stopping the medication.
Common skin effects of Bupropion
According to the prescribing information for Bupropion, common skin reactions include mild rash, dryness, mild itching, transient flushing and (for some agents) photosensitivity that makes the skin more sensitive to UV. Bupropion inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin reuptake. Most are mild, appear in the first weeks and resolve without intervention or with simple measures (moisturiser, sunscreen).
Serious skin reactions
Severe skin reactions — Stevens-Johnson syndrome, toxic epidermal necrolysis, drug-induced hypersensitivity syndrome — are rare but life-threatening. Warning signs are a rash with fever, mucosal involvement (mouth, eyes), skin peeling, or rapidly spreading rash. Any of these on Bupropion at 75mg, 100mg, 150mg, 300mg is a medical emergency and reason to stop the medication and seek immediate care.
Frequently asked questions
Is a rash on Bupropion dangerous? ▾
Most rashes on Bupropion at 75mg, 100mg, 150mg, 300mg are mild and resolve. A rash with fever, mucosal involvement, blistering or rapid spread is not — it requires emergency evaluation and stopping the medication.
Can Bupropion cause sunburn or photosensitivity? ▾
Some medications including a subset of Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant agents increase UV sensitivity, making sunburn occur faster. The prescribing information for Bupropion lists this when documented. Sunscreen and avoiding peak sun exposure manage the risk.
Products containing Bupropion
More on Bupropion
- With alcoholBupropion and alcohol — is it safe to drink?
- With foodShould Bupropion be taken with food?
- Side effectsBupropion side effects: common, rare and warning signs
- Dosage guideBupropion dosage guide: how much to take and when
- OnsetHow fast does Bupropion start working?
- DurationHow long does Bupropion last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.