Norepinephrine-dopamine reuptake inhibitor (NDRI) antidepressant
Who should not take Bupropion
A contraindication is a condition under which Bupropion (Bupropion) should not be taken because the risk outweighs the benefit. Bupropion has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 75mg, 100mg, 150mg, 300mg dosing range.
Absolute contraindications
According to the prescribing information for Bupropion, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Bupropion can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Bupropion inhibits the reuptake of norepinephrine and dopamine, with much weaker effect on serotonin reuptake.
Frequently asked questions
Can someone with heart disease take Bupropion? ▾
Some forms of heart disease are absolute contraindications for Bupropion, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Bupropion use under specialist supervision. The prescribing information for Bupropion should be reviewed.
Is Bupropion safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Bupropion at adjusted lower 75mg, 100mg, 150mg, 300mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Bupropion
More on Bupropion
- With alcoholBupropion and alcohol — is it safe to drink?
- With foodShould Bupropion be taken with food?
- Side effectsBupropion side effects: common, rare and warning signs
- Dosage guideBupropion dosage guide: how much to take and when
- OnsetHow fast does Bupropion start working?
- DurationHow long does Bupropion last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.