Macrolide antibiotic
Who should not take Azithromycin
A contraindication is a condition under which Azithromycin (Azithromycin) should not be taken because the risk outweighs the benefit. Azithromycin has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 250mg, 500mg, 600mg dosing range.
Absolute contraindications
According to the prescribing information for Azithromycin, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Azithromycin can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Azithromycin reversibly binds the 50S ribosomal subunit of susceptible bacteria, inhibiting protein synthesis.
Frequently asked questions
Can someone with heart disease take Azithromycin? ▾
Some forms of heart disease are absolute contraindications for Azithromycin, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Azithromycin use under specialist supervision. The prescribing information for Azithromycin should be reviewed.
Is Azithromycin safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Azithromycin at adjusted lower 250mg, 500mg, 600mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
Products containing Azithromycin
More on Azithromycin
- With alcoholAzithromycin and alcohol — is it safe to drink?
- With foodShould Azithromycin be taken with food?
- Side effectsAzithromycin side effects: common, rare and warning signs
- Dosage guideAzithromycin dosage guide: how much to take and when
- OnsetHow fast does Azithromycin start working?
- DurationHow long does Azithromycin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.