Phosphodiesterase type 5 (PDE5) inhibitor
Avanafil with kidney impairment: dosing and safety
Kidney function affects how the body clears Avanafil (Avanafil) and many of its metabolites. For people with chronic kidney disease, dialysis, or even mild renal impairment from age or comorbidities, the standard 50mg, 100mg, 200mg dose may need adjustment. This page summarises the practical principles for Avanafil in renal impairment.
Why renal function matters for Avanafil
A meaningful fraction of Avanafil or its active metabolites is cleared by the kidneys for many medications. Reduced eGFR slows clearance, raises plasma concentrations and prolongs effect. Avanafil selectively inhibits phosphodiesterase type 5 (PDE5) in the corpus cavernosum, increasing cGMP and enhancing nitric-oxide-mediated vasodilation in response to sexual stimulation. The prescribing information for Avanafil usually specifies dose adjustments by eGFR threshold (e.g. 30–60 vs <30 mL/min/1.73m²).
Practical guidance
According to the prescribing information, baseline kidney function should be checked before starting Avanafil and periodically during treatment. People on dialysis need specialist input on dose timing relative to dialysis. Acute kidney injury — from dehydration, infection or other medications — can shift Avanafil effects unpredictably and may warrant a temporary hold at 50mg, 100mg, 200mg.
Frequently asked questions
Is Avanafil safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Avanafil at adjusted lower 50mg, 100mg, 200mg doses with monitoring. Severe impairment (eGFR <30) often requires substantial reduction or alternative therapy. The prescriber decides based on lab results and the indication.
Do I need lab tests on Avanafil if I have kidney disease? ▾
Yes — periodic eGFR and electrolyte monitoring is the standard practice for Avanafil in chronic kidney disease. Frequency depends on the severity of impairment and on Avanafil-specific risks. The prescriber sets the schedule.
Products containing Avanafil
More on Avanafil
- With alcoholAvanafil and alcohol — is it safe to drink?
- With foodShould Avanafil be taken with food?
- Side effectsAvanafil side effects: common, rare and warning signs
- Dosage guideAvanafil dosage guide: how much to take and when
- OnsetHow fast does Avanafil start working?
- DurationHow long does Avanafil last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.