Potassium-sparing diuretic
Amiloride with antibiotics: interactions and safety
Antibiotic courses are common, short-term and often combined with chronic medications such as Amiloride (Amiloride). Most antibiotics do not interfere meaningfully with Amiloride at 5mg, but a few classes do, and a small number of combinations are best avoided.
Common antibiotic interactions
Macrolides (clarithromycin, erythromycin) and certain antifungals can inhibit hepatic metabolism (CYP3A4) and raise plasma levels of many medications including some Potassium-sparing diuretic agents. Rifampicin has the opposite effect, accelerating metabolism. Most penicillins, cephalosporins, fluoroquinolones and tetracyclines have no clinically meaningful interaction with Amiloride at 5mg.
Practical guidance
According to the prescribing information for Amiloride, an antibiotic course should be reviewed by the prescriber or pharmacist for known interactions before Amiloride is co-administered. Adjusted 5mg dosing or temporary substitution is sometimes preferred for the duration of the antibiotic course.
Frequently asked questions
Can I take Amiloride during an antibiotic course? ▾
For most common antibiotics, yes. A few classes — notably macrolides and azole antifungals — alter how Amiloride is metabolised and may need a temporary 5mg adjustment. The prescribing pharmacist should review any new antibiotic against the existing Amiloride regimen.
Will antibiotics make Amiloride stop working? ▾
Most antibiotics do not affect Amiloride efficacy. Rifampicin and a few others can lower Amiloride levels and reduce effect; in those cases the prescriber may adjust the dose during and shortly after the antibiotic course.
Products containing Amiloride
More on Amiloride
- With alcoholAmiloride and alcohol — is it safe to drink?
- With foodShould Amiloride be taken with food?
- Side effectsAmiloride side effects: common, rare and warning signs
- Dosage guideAmiloride dosage guide: how much to take and when
- OnsetHow fast does Amiloride start working?
- DurationHow long does Amiloride last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.