Clearance
How quickly the body removes a drug, mainly through the liver and kidneys.
Clearance is the rate at which a drug is irreversibly removed from the bloodstream, usually by the liver breaking it down or the kidneys filtering it out. It is the main reason doses are adjusted in kidney or liver impairment: if clearance falls, the same dose produces a higher concentration and the drug accumulates. Clearance together with dose determines the steady-state level, and clearance together with volume of distribution determines the half-life.
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