What to do if you miss a dose of Zoloft

Missing a dose of Zoloft (Sertraline) is common — most people will skip a dose at some point during a course. The right action depends on how long since the missed dose and whether Zoloft is taken event-driven or daily at 25mg, 50mg, 100mg. The wrong action — doubling up — is not recommended.

For daily Zoloft

If Zoloft is taken daily for a chronic condition, take the missed dose as soon as you remember, unless it is almost time for the next scheduled dose. In that case skip the missed dose and continue normally. According to the prescribing information for Sertraline, two doses should never be taken close together to "make up" for a miss.

For event-driven Zoloft

If Zoloft is used as needed (not on a fixed schedule), there is no "missed dose" in the conventional sense — simply take the planned dose when needed and observe the recommended gap before re-dosing. Sertraline acts by selectively blocking the serotonin transporter, preventing serotonin reuptake from the synaptic cleft and increasing synaptic serotonin concentration.

Frequently asked questions

Should I double the dose if I missed Zoloft? ▾

No. Doubling doses of Zoloft to compensate is not recommended at any 25mg, 50mg, 100mg strength and increases the risk of side effects without improving efficacy. Take the next scheduled dose normally.

How many missed doses are too many? ▾

Occasional missed doses of Zoloft are usually inconsequential. Repeated missed doses can compromise the therapeutic effect — for chronic conditions like those treated with Anti-Depressants, consistent dosing matters. If adherence is hard, discuss reminders, simpler schedules or alternative formulations with the prescriber.

More on Zoloft

The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.