Who should not take Zoloft
A contraindication is a condition under which Zoloft (Sertraline) should not be taken because the risk outweighs the benefit. Zoloft has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 25mg, 50mg, 100mg dosing range.
Absolute contraindications
According to the prescribing information for Sertraline, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Zoloft can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Sertraline acts by selectively blocking the serotonin transporter, preventing serotonin reuptake from the synaptic cleft and increasing synaptic serotonin concentration.
Frequently asked questions
Can someone with heart disease take Zoloft? ▾
Some forms of heart disease are absolute contraindications for Zoloft, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Zoloft use under specialist supervision. The prescribing information for Sertraline should be reviewed.
Is Zoloft safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Zoloft at adjusted lower 25mg, 50mg, 100mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Zoloft
- With alcoholZoloft and alcohol — is it safe to drink?
- With foodShould Zoloft be taken with food?
- Side effectsZoloft side effects: common, rare and warning signs
- Dosage guideZoloft dosage guide: how much to take and when
- OnsetHow fast does Zoloft start working?
- DurationHow long does Zoloft last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.