Who should not take Valtrex
A contraindication is a condition under which Valtrex (Valacyclovir) should not be taken because the risk outweighs the benefit. Valtrex has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 500mg, 1000mg dosing range.
Absolute contraindications
According to the prescribing information for Valacyclovir, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Valtrex can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Valacyclovir is rapidly and almost completely converted to acyclovir during first-pass intestinal and hepatic metabolism by valacyclovir hydrolase.
Frequently asked questions
Can someone with heart disease take Valtrex? ▾
Some forms of heart disease are absolute contraindications for Valtrex, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Valtrex use under specialist supervision. The prescribing information for Valacyclovir should be reviewed.
Is Valtrex safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Valtrex at adjusted lower 500mg, 1000mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Valtrex
- With alcoholValtrex and alcohol — is it safe to drink?
- With foodShould Valtrex be taken with food?
- Side effectsValtrex side effects: common, rare and warning signs
- Dosage guideValtrex dosage guide: how much to take and when
- OnsetHow fast does Valtrex start working?
- DurationHow long does Valtrex last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.