Who should not take Trulicity
A contraindication is a condition under which Trulicity (Dulaglutide) should not be taken because the risk outweighs the benefit. Trulicity has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 0.75mg, 1.5mg, 3mg, 4.5mg dosing range.
Absolute contraindications
According to the prescribing information for Dulaglutide, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Trulicity can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. After subcutaneous injection, dulaglutide is gradually absorbed and circulates with greater than 99% albumin binding.
Frequently asked questions
Can someone with heart disease take Trulicity? ▾
Some forms of heart disease are absolute contraindications for Trulicity, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Trulicity use under specialist supervision. The prescribing information for Dulaglutide should be reviewed.
Is Trulicity safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Trulicity at adjusted lower 0.75mg, 1.5mg, 3mg, 4.5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Trulicity
- With alcoholTrulicity and alcohol — is it safe to drink?
- With foodShould Trulicity be taken with food?
- Side effectsTrulicity side effects: common, rare and warning signs
- Dosage guideTrulicity dosage guide: how much to take and when
- OnsetHow fast does Trulicity start working?
- DurationHow long does Trulicity last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.