Synthroid and cannabis (marijuana, THC)
As cannabis becomes legal or decriminalised in more jurisdictions, the practical question of combining it with prescription medication comes up regularly. Synthroid (Levothyroxine) and cannabis share several pharmacological pathways, and the combination at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg is not automatically benign even where both are legal.
How cannabis affects Synthroid
THC and other cannabinoids are metabolised partly by hepatic CYP enzymes, including CYP3A4 — the same pathway used by many Hormones and Birth Control medications. Frequent cannabis use can shift the metabolism of Levothyroxine mildly. THC also has cardiovascular effects (increased heart rate, blood pressure changes) and central nervous system effects that can stack with Synthroid's side-effect profile.
Practical guidance
Occasional moderate cannabis use is unlikely to cause clinically meaningful problems for most adults on Synthroid at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg. Heavy daily use, edibles with high THC content, or cannabis combined with alcohol substantially raise the risk of dizziness, hypotension, impaired judgement and amplified side effects from Levothyroxine. According to the prescribing information, the full list of recreational substances should be disclosed to the prescriber.
Frequently asked questions
Can I use cannabis while taking Synthroid? ▾
For most adults at 25mcg, 50mcg, 75mcg, 100mcg, 150mcg, occasional moderate cannabis is tolerated, but heavy daily use is not advised because of metabolic and additive cardiovascular effects with Levothyroxine. The safe practice is to mention it to the prescriber.
Does CBD interact with Synthroid? ▾
CBD inhibits several CYP enzymes including CYP3A4, which can raise plasma levels of medications that go through that pathway. For Synthroid specifically, this depends on whether Levothyroxine uses CYP3A4. Daily high-dose CBD products warrant a pharmacist check.
More on Synthroid
- With alcoholSynthroid and alcohol — is it safe to drink?
- With foodShould Synthroid be taken with food?
- Side effectsSynthroid side effects: common, rare and warning signs
- Dosage guideSynthroid dosage guide: how much to take and when
- OnsetHow fast does Synthroid start working?
- DurationHow long does Synthroid last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.