Stendra with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Stendra (Avanafil). The combination is generally fine at 50mg, 100mg, 200mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Stendra can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Avanafil acts on CYP3A4 determines whether Stendra affects contraception. Most agents in Erectile Dysfunction (ED) have no clinically meaningful effect on the pill at 50mg, 100mg, 200mg.
Practical guidance
According to the prescribing information for Avanafil, women on hormonal contraception should review Stendra with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Stendra therapy is the standard mitigation.
Frequently asked questions
Will Stendra make my pill less effective? ▾
Most Erectile Dysfunction (ED) medications at 50mg, 100mg, 200mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Avanafil states whether the interaction is meaningful.
Do I need a backup contraceptive on Stendra? ▾
Backup contraception is needed only when there is a documented interaction between Stendra and the contraceptive method. For most users at 50mg, 100mg, 200mg, no backup is required. The pharmacist confirms whether Avanafil interacts with hormonal contraception.
More on Stendra
- With alcoholStendra and alcohol — is it safe to drink?
- With foodShould Stendra be taken with food?
- Side effectsStendra side effects: common, rare and warning signs
- Dosage guideStendra dosage guide: how much to take and when
- OnsetHow fast does Stendra start working?
- DurationHow long does Stendra last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.