Prometrium for men: indications and considerations
Some medications are licensed only for men, others have male-specific dosing patterns, and many are used across both sexes. This page covers how Prometrium (Progesterone) is used in men, in the context of its Hormones and Birth Control indications and 100mg, 200mg dosing pattern.
Prometrium in men: typical use
Prometrium contains Progesterone and is used for Prometrium is approved for endometrial protection in postmenopausal women receiving estrogen, secondary amenorrhoea and selected ART indications.. The 100mg, 200mg dose options reflect typical adult male dosing where applicable. Older men, men with cardiovascular disease, and men on multiple chronic medications often need adjusted doses or monitoring.
Male-specific considerations
Important considerations include cardiovascular history, prostate health, fertility plans where relevant, and interactions with common male-prescribed medications such as alpha-blockers and certain antihypertensives. Progesterone in Prometrium binds to progesterone receptors and modulates gene expression in reproductive and other tissues. Most prescribers also screen for nitrate use, which is a hard contraindication for several drugs in this class.
Frequently asked questions
Is Prometrium safe for men? ▾
For most adult men without cardiovascular disease, severe liver or kidney impairment, or other significant comorbidity, Prometrium at standard 100mg, 200mg is well tolerated. The prescribing information for Progesterone lists specific contraindications that should be reviewed before starting.
Does Prometrium affect testosterone or fertility? ▾
Effects on testosterone or fertility depend on the active ingredient. Some medications in Hormones and Birth Control have neutral effects, others can affect hormone levels or sperm parameters. Men with fertility plans should discuss Prometrium with the prescriber before starting.
More on Prometrium
- With alcoholPrometrium and alcohol — is it safe to drink?
- With foodShould Prometrium be taken with food?
- Side effectsPrometrium side effects: common, rare and warning signs
- Dosage guidePrometrium dosage guide: how much to take and when
- OnsetHow fast does Prometrium start working?
- DurationHow long does Prometrium last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.