Plan B with antidepressants: interactions
Many adults take an antidepressant for mood, anxiety or chronic pain. The combination with Plan B (Levonorgestrel) is common and, for most antidepressant classes, well tolerated. A few specific combinations require attention because of additive effects or shared metabolic pathways.
Antidepressant interaction landscape
SSRIs, SNRIs, TCAs, MAOIs and atypical antidepressants each interact differently. SSRIs are the most commonly co-prescribed and usually have minor or no clinically meaningful interaction with Levonorgestrel at 1.5mg. MAOIs require special caution with many medications. Tricyclics can amplify cardiovascular and sedative effects of some Hormones and Birth Control agents.
Practical guidance
According to the prescribing information for Levonorgestrel, any change in antidepressant therapy should be reviewed alongside Plan B dosing. Switching antidepressants — particularly to or from MAOIs — usually requires a washout period before resuming Plan B at the standard 1.5mg schedule.
Frequently asked questions
Can I take Plan B on an SSRI? ▾
For most SSRIs and most Hormones and Birth Control agents, the combination is acceptable with normal monitoring. A few combinations require dose adjustment or alternative selection. The prescriber confirms based on the specific antidepressant and the active ingredient Levonorgestrel.
Are there antidepressants to avoid with Plan B? ▾
MAOIs are the antidepressant class most often flagged for caution with many medications. Other interactions depend on Levonorgestrel and the specific antidepressant; a pharmacist review is the practical safeguard at 1.5mg.
More on Plan B
- With alcoholPlan B and alcohol — is it safe to drink?
- With foodShould Plan B be taken with food?
- Side effectsPlan B side effects: common, rare and warning signs
- Dosage guidePlan B dosage guide: how much to take and when
- OnsetHow fast does Plan B start working?
- DurationHow long does Plan B last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.