Lyrica with the birth control pill
Many women of reproductive age take a combined or progestogen-only oral contraceptive while also using a chronic medication such as Lyrica (Pregabalin). The combination is generally fine at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg, but a small number of medications can reduce contraceptive efficacy meaningfully and need either a backup method or a switch.
How Lyrica can affect contraceptive efficacy
Combined and progestogen-only contraceptives are metabolised through CYP3A4. Strong CYP3A4 inducers (some antiepileptics, rifampicin, St John's Wort) lower contraceptive plasma levels and reduce efficacy. Whether Pregabalin acts on CYP3A4 determines whether Lyrica affects contraception. Most agents in Pain Relief Medications have no clinically meaningful effect on the pill at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg.
Practical guidance
According to the prescribing information for Pregabalin, women on hormonal contraception should review Lyrica with the prescribing pharmacist or doctor. Where an interaction is documented, additional barrier contraception or switching to a non-oral method (IUD, implant) for the duration of Lyrica therapy is the standard mitigation.
Frequently asked questions
Will Lyrica make my pill less effective? ▾
Most Pain Relief Medications medications at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg do not affect oral contraceptive efficacy. The exceptions are CYP3A4-inducing drugs and a small number of others. The prescribing information for Pregabalin states whether the interaction is meaningful.
Do I need a backup contraceptive on Lyrica? ▾
Backup contraception is needed only when there is a documented interaction between Lyrica and the contraceptive method. For most users at 25mg, 50mg, 75mg, 100mg, 150mg, 200mg, 225mg, 300mg, no backup is required. The pharmacist confirms whether Pregabalin interacts with hormonal contraception.
More on Lyrica
- With alcoholLyrica and alcohol — is it safe to drink?
- With foodShould Lyrica be taken with food?
- Side effectsLyrica side effects: common, rare and warning signs
- Dosage guideLyrica dosage guide: how much to take and when
- OnsetHow fast does Lyrica start working?
- DurationHow long does Lyrica last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.