Who should not take Diflucan
A contraindication is a condition under which Diflucan (Fluconazole) should not be taken because the risk outweighs the benefit. Diflucan has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 50mg, 100mg, 150mg, 200mg dosing range.
Absolute contraindications
According to the prescribing information for Fluconazole, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Diflucan can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Fluconazole is a triazole antifungal that inhibits the cytochrome P450-dependent enzyme lanosterol 14-alpha-demethylase, blocking the synthesis of ergosterol from lanosterol.
Frequently asked questions
Can someone with heart disease take Diflucan? ▾
Some forms of heart disease are absolute contraindications for Diflucan, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Diflucan use under specialist supervision. The prescribing information for Fluconazole should be reviewed.
Is Diflucan safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Diflucan at adjusted lower 50mg, 100mg, 150mg, 200mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Diflucan
- With alcoholDiflucan and alcohol — is it safe to drink?
- With foodShould Diflucan be taken with food?
- Side effectsDiflucan side effects: common, rare and warning signs
- Dosage guideDiflucan dosage guide: how much to take and when
- OnsetHow fast does Diflucan start working?
- DurationHow long does Diflucan last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.