Who should not take Cymbalta

A contraindication is a condition under which Cymbalta (Duloxetine) should not be taken because the risk outweighs the benefit. Cymbalta has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 20mg, 30mg, 60mg dosing range.

Absolute contraindications

According to the prescribing information for Duloxetine, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.

Relative cautions

Relative cautions are situations where Cymbalta can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Cymbalta inhibits the reuptake of both serotonin and norepinephrine at the synapse.

Frequently asked questions

Can someone with heart disease take Cymbalta? ▾

Some forms of heart disease are absolute contraindications for Cymbalta, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Cymbalta use under specialist supervision. The prescribing information for Duloxetine should be reviewed.

Is Cymbalta safe with kidney problems? ▾

Mild to moderate kidney impairment usually allows Cymbalta at adjusted lower 20mg, 30mg, 60mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.

More on Cymbalta

The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.