Who should not take Crestor
A contraindication is a condition under which Crestor (Rosuvastatin) should not be taken because the risk outweighs the benefit. Crestor has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 5mg, 10mg, 20mg, 40mg dosing range.
Absolute contraindications
According to the prescribing information for Rosuvastatin, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Crestor can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Rosuvastatin competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in hepatic cholesterol synthesis.
Frequently asked questions
Can someone with heart disease take Crestor? ▾
Some forms of heart disease are absolute contraindications for Crestor, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Crestor use under specialist supervision. The prescribing information for Rosuvastatin should be reviewed.
Is Crestor safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Crestor at adjusted lower 5mg, 10mg, 20mg, 40mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Crestor
- With alcoholCrestor and alcohol — is it safe to drink?
- With foodShould Crestor be taken with food?
- Side effectsCrestor side effects: common, rare and warning signs
- Dosage guideCrestor dosage guide: how much to take and when
- OnsetHow fast does Crestor start working?
- DurationHow long does Crestor last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.