Who should not take Aygestin
A contraindication is a condition under which Aygestin (Norethindrone Acetate) should not be taken because the risk outweighs the benefit. Aygestin has both absolute contraindications (do not use) and relative cautions (use only after careful review). This page summarises both at the 5mg dosing range.
Absolute contraindications
According to the prescribing information for Norethindrone, absolute contraindications typically include severe allergic reactions to the active ingredient or excipients, severe hepatic or renal impairment, certain cardiovascular conditions, and concurrent use of specific interacting medications. The exact list depends on the molecule and is detailed in the official label.
Relative cautions
Relative cautions are situations where Aygestin can be used but with extra monitoring, dose reduction or alternative considered. These often include mild-to-moderate organ impairment, age extremes, multiple comorbidities, and complex medication regimens. Norethindrone binds to progesterone receptors and exerts progestational effects: thickening cervical mucus, suppressing the LH surge, thinning the endometrium and reducing endometrial implant activity…
Frequently asked questions
Can someone with heart disease take Aygestin? ▾
Some forms of heart disease are absolute contraindications for Aygestin, particularly with nitrate use or recent cardiovascular events. Stable, well-controlled cardiovascular disease may allow Aygestin use under specialist supervision. The prescribing information for Norethindrone should be reviewed.
Is Aygestin safe with kidney problems? ▾
Mild to moderate kidney impairment usually allows Aygestin at adjusted lower 5mg doses. Severe kidney failure is often a contraindication or requires substantial dose reduction. The prescriber decides based on lab results and concurrent medications.
More on Aygestin
- With alcoholAygestin and alcohol — is it safe to drink?
- With foodShould Aygestin be taken with food?
- Side effectsAygestin side effects: common, rare and warning signs
- Dosage guideAygestin dosage guide: how much to take and when
- OnsetHow fast does Aygestin start working?
- DurationHow long does Aygestin last?
The information on this website is provided for reference and educational purposes only. It does not replace consultation with a qualified healthcare professional.